<i>PDE4</i> Gene Family Variants Are Associated with Response to Apremilast Treatment in Psoriasis

<i>PDE4</i> Gene Family Variants Are Associated with Response to Apremilast Treatment in Psoriasis

Moderate-to-severe psoriasis (Ps) treatment includes systemic drugs and biological agents. Apremilast, a small molecule primarily metabolized by cytochrome CYP3A4, modulates the immune system by specifically inhibiting phosphodiesterase type 4 (PDE4) isoforms and is currently used for the treatment...

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Bibliographic Details
Main Authors: Kalliopi Liadaki, Efterpi Zafiriou, Themistoklis Giannoulis, Sofia Alexouda, Kleoniki Chaidaki, Polyxeni Gidarokosta, Angeliki-Viktoria Roussaki-Schulze, Sotirios G. Tsiogkas, Athina Daponte, Zissis Mamuris, Dimitrios P. Bogdanos, Nicholas K. Moschonas, Theologia Sarafidou
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Genes
Subjects:
apremilast
psoriasis
association study
SNP
PDE4
CYP3A4
Online Access:https://www.mdpi.com/2073-4425/15/3/369

Internet

https://www.mdpi.com/2073-4425/15/3/369

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