Formalin Removal from Archival Tissue by Critical Point Drying
The extraction of high-quality nucleic acid may be problematic in formalin-fixed tissues because of cross-linking between proteins and DNA. Old fixed tissue specimens do produce fragmented DNA (<1.2 kb), which is only used for PCR amplification. Here we show that high molecular weight DNA (>19...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2002-09-01
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| Series: | BioTechniques |
| Online Access: | https://www.future-science.com/doi/10.2144/02333rr03 |