<i>JAK2</i> Variant Signaling: Genetic, Hematologic and Immune Implication in Chronic Myeloproliferative Neoplasms

<i>JAK2</i> Variant Signaling: Genetic, Hematologic and Immune Implication in Chronic Myeloproliferative Neoplasms

The <i>JAK2</i>V617F variant constitutes a genetic alteration of higher frequency in BCR/ABL1 negative chronic myeloproliferative neoplasms, which is caused by a substitution of a G ˃ T at position 1849 and results in the substitution of valine with phenylalanine at codon 617 of the poly...

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Bibliographic Details
Main Authors: Dania G. Torres, Jhemerson Paes, Allyson G. da Costa, Adriana Malheiro, George V. Silva, Lucivana P. de Souza Mourão, Andréa M. Tarragô
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Biomolecules
Subjects:
<i>JAK2</i>V617F signaling
myeloproliferative neoplasms
clonal hematopoiesis
hemostasis
immunothrombosis
immune response
Online Access:https://www.mdpi.com/2218-273X/12/2/291

Internet

https://www.mdpi.com/2218-273X/12/2/291

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