Pharmacological study on the enhancing effects of U46619 on guinea pig urinary bladder smooth muscle contraction induced by acetylcholine and α,β-methylene ATP and the possible involvement of protein kinase C

Pharmacological study on the enhancing effects of U46619 on guinea pig urinary bladder smooth muscle contraction induced by acetylcholine and α,β-methylene ATP and the possible involvement of protein kinase C

We examined whether U46619 (a prostanoid TP receptor agonist) could enhance the contractions of guinea pig urinary bladder smooth muscle (UBSM) in response to acetylcholine (ACh) and an ATP analog (α,β-methylene ATP (αβ-MeATP)) through stimulation of the UBSM TP receptor and whether protein kinase C...

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Bibliographic Details
Main Authors: Guanghan Ou, Akane Komura, Misaki Hojo, Rina Kato, Masahiro Ikeda, Miki Fujisawa, Keyue Xu, Kento Yoshioka, Keisuke Obara, Yoshio Tanaka
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Journal of Pharmacological Sciences
Subjects:
U46619 (a prostanoid TP receptor agonist)
Urinary bladder smooth muscle
Protein kinase C (PKC)
α,β-methylene ATP
Acetylcholine
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861323000518

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