The Effect of Clozapine and Novel Glutamate Modulator JNJ-46356479 on Nitrosative Stress in a Postnatal Murine Ketamine Model of Schizophrenia

The Effect of Clozapine and Novel Glutamate Modulator JNJ-46356479 on Nitrosative Stress in a Postnatal Murine Ketamine Model of Schizophrenia

Schizophrenia (SZ) is a heterogeneous mental disorder, affecting ~1% of the worldwide population. One of the main pathophysiological theories of SZ is the imbalance of excitatory glutamatergic pyramidal neurons and inhibitory GABAergic interneurons, involving N-methyl-D-aspartate receptors (NMDAr)....

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Bibliographic Details
Main Authors: Nina Treder, Albert Martínez-Pinteño, Natalia Rodríguez, Néstor Arbelo, Santiago Madero, Marta Gómez, Clemente García-Rizo, Sergi Mas, Patricia Gassó, Eduard Parellada, Constanza Morén
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
clozapine
glutamate metabotropic modulator
ketamine
nitrosative stress
schizophrenia
Online Access:https://www.mdpi.com/1422-0067/24/2/1022

Internet

https://www.mdpi.com/1422-0067/24/2/1022

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