ELFN1-AS1 promotes GDF15-mediated immune escape of colorectal cancer from NK cells by facilitating GCN5 and SND1 association

ELFN1-AS1 promotes GDF15-mediated immune escape of colorectal cancer from NK cells by facilitating GCN5 and SND1 association

Abstract The ability of colorectal cancer (CRC) cells to escape from natural killer (NK) cell immune surveillance leads to anti-tumor treatment failure. The long non-coding RNA (lncRNA) ELFN1-AS1 is aberrantly expressed in multiple tumors suggesting a role as an oncogene in cancer development. Howev...

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Bibliographic Details
Main Authors: Bin Han, Jinsong He, Qing Chen, Min Yuan, Xi Zeng, Yuanting Li, Yan Zeng, Meibo He, Qilin Zhou, Dan Feng, Daiyuan Ma
Format: Article
Language:English
Published: Springer 2023-05-01
Series:Discover Oncology
Subjects:
Nature killer cell
ELFN1-AS1
GDF15
SND1
Colorectal cancer
GCN5
Online Access:https://doi.org/10.1007/s12672-023-00675-6

Internet

https://doi.org/10.1007/s12672-023-00675-6

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