A novel H129-based anterograde monosynaptic tracer exhibits features of strong labeling intensity, high tracing efficiency, and reduced retrograde labeling

A novel H129-based anterograde monosynaptic tracer exhibits features of strong labeling intensity, high tracing efficiency, and reduced retrograde labeling

Abstract Background Viral tracers are important tools for mapping brain connectomes. The feature of predominant anterograde transneuronal transmission offers herpes simplex virus-1 (HSV-1) strain H129 (HSV1-H129) as a promising candidate to be developed as anterograde viral tracers. In our earlier s...

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Bibliographic Details
Main Authors: Hong Yang, Feng Xiong, Hai-Bin Qin, Qun-Tao Yu, Jin-Yan Sun, Hai-Wen Zhao, Dong Li, Youtong Zhou, Fu-Kun Zhang, Xiao-Wen Zhu, Tong Wu, Man Jiang, Xiangmin Xu, Youming Lu, Hong-Jie Shen, Wen-Bo Zeng, Fei Zhao, Min-Hua Luo
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Molecular Neurodegeneration
Subjects:
H129-dgK-G4
Anterograde monosynaptic tracer
Glycoprotein K (gK)
Mutant gK pseudotyping
Labeling intensity
Tracing efficiency
Online Access:https://doi.org/10.1186/s13024-021-00508-6

Internet

https://doi.org/10.1186/s13024-021-00508-6

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