The Impact of Genetic Polymorphisms in Glutamate-Cysteine Ligase, a Key Enzyme of Glutathione Biosynthesis, on Ischemic Stroke Risk and Brain Infarct Size

The Impact of Genetic Polymorphisms in Glutamate-Cysteine Ligase, a Key Enzyme of Glutathione Biosynthesis, on Ischemic Stroke Risk and Brain Infarct Size

The purpose of this pilot study was to explore whether polymorphisms in genes encoding the catalytic (<i>GCLC</i>) and modifier (<i>GCLM</i>) subunits of glutamate-cysteine ligase, a rate-limiting enzyme in glutathione synthesis, play a role in the development of ischemic str...

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Bibliographic Details
Main Authors: Alexey Polonikov, Iuliia Bocharova, Iuliia Azarova, Elena Klyosova, Marina Bykanova, Olga Bushueva, Anna Polonikova, Mikhail Churnosov, Maria Solodilova
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Life
Subjects:
ischemic stroke
brain infarction
oxidative stress
glutathione
<i>GCLC</i>
<i>GCLM</i>
Online Access:https://www.mdpi.com/2075-1729/12/4/602

Internet

https://www.mdpi.com/2075-1729/12/4/602

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