Activation of Kir2.1 improves myocardial fibrosis by inhibiting Ca <sup>2+</sup> overload and the TGF-β1/Smad signaling pathway

The inwardly rectifying potassium channel Kir2.1 is closely associated with many cardiovascular diseases. However, the effect and mechanism of Kir2.1 in diabetic cardiomyopathy remain unclear. In vivo, we use STZ to establish the model, and ventricular structural changes, myocard...

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Bibliographic Details
Main Authors: Rong Yi, Zhou Xin, Guo Zhenli, Zhang Yingying, Qin Wenjuan, Li Li, Si Junqiang, Yang Rui, Li Xinzhi, Ma Ketao
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2023-05-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2023083