Allele-specific expression analysis for complex genetic phenotypes applied to a unique dilated cardiomyopathy cohort

Allele-specific expression analysis for complex genetic phenotypes applied to a unique dilated cardiomyopathy cohort

Abstract Allele-specific expression (ASE) analysis detects the relative abundance of alleles at heterozygous loci as a proxy for cis-regulatory variation, which affects the personal transcriptome and proteome. This study describes the development and application of an ASE analysis pipeline on a uniq...

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Bibliographic Details
Main Authors: Daan van Beek, Job Verdonschot, Kasper Derks, Han Brunner, Theo M. de Kok, Ilja C. W. Arts, Stephane Heymans, Martina Kutmon, Michiel Adriaens
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-27591-7

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https://doi.org/10.1038/s41598-023-27591-7

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