The Salvinorin Analogue, Ethoxymethyl Ether Salvinorin B, Promotes Remyelination in Preclinical Models of Multiple Sclerosis

The Salvinorin Analogue, Ethoxymethyl Ether Salvinorin B, Promotes Remyelination in Preclinical Models of Multiple Sclerosis

Multiple sclerosis is a neurodegenerative disease associated with demyelination and neuroinflammation in the central nervous system. There is an urgent need to develop remyelinating therapies to better treat multiple sclerosis and other demyelinating diseases. The kappa opioid receptor (KOR) has bee...

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Bibliographic Details
Main Authors: Kelly F. Paton, Katharina Robichon, Nikki Templeton, Lisa Denny, Afnan Al Abadey, Dan Luo, Thomas E. Prisinzano, Anne C. La Flamme, Bronwyn M. Kivell
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Neurology
Subjects:
multiple sclerosis
kappa opioid receptor
experimental autoimmune encephalomyelitis
salvinorin A analog
remyelination
cuprizone-induced demyelination
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.782190/full

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https://www.frontiersin.org/articles/10.3389/fneur.2021.782190/full

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