Thermal proteome profiling in bacteria: probing protein state in vivo

Thermal proteome profiling in bacteria: probing protein state in vivo

Abstract Increasing antibiotic resistance urges for new technologies for studying microbes and antimicrobial mechanism of action. We adapted thermal proteome profiling (TPP) to probe the thermostability of Escherichia coli proteins in vivo. E. coli had a more thermostable proteome than human cells,...

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Bibliographic Details
Main Authors: André Mateus, Jacob Bobonis, Nils Kurzawa, Frank Stein, Dominic Helm, Johannes Hevler, Athanasios Typas, Mikhail M Savitski
Format: Article
Language:English
Published: Springer Nature 2018-07-01
Series:Molecular Systems Biology
Subjects:
Escherichia coli
metabolic pathways
protein complexes
target engagement
thermal proteome profiling
Online Access:https://doi.org/10.15252/msb.20188242

Internet

https://doi.org/10.15252/msb.20188242

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