The Metastatic Bone Marrow Niche in Neuroblastoma: Altered Phenotype and Function of Mesenchymal Stromal Cells

The Metastatic Bone Marrow Niche in Neuroblastoma: Altered Phenotype and Function of Mesenchymal Stromal Cells

<i>Background</i>: The bone marrow (BM) is the main site of metastases and relapse in patients with neuroblastoma (NB). BM-residing mesenchymal stromal cells (MSCs) were shown to promote tumor cell survival and chemoresistance. Here we characterize the MSC compartment of the metastatic N...

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Bibliographic Details
Main Authors: Caroline Hochheuser, Lieke M. J. van Zogchel, Marion Kleijer, Carlijn Kuijk, Simon Tol, C. Ellen van der Schoot, Carlijn Voermans, Godelieve A. M. Tytgat, Ilse Timmerman
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
neuroblastoma
mesenchymal stromal cell
bone marrow
microenvironment
metastasis
Online Access:https://www.mdpi.com/2072-6694/12/11/3231

Internet

https://www.mdpi.com/2072-6694/12/11/3231

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