Single-cell RNA-seq analysis reveals that immune cells induce human nucleus pulposus ossification and degeneration

Single-cell RNA-seq analysis reveals that immune cells induce human nucleus pulposus ossification and degeneration

Background and aimsDetermining the transcriptomes and molecular mechanism underlying human degenerative nucleus pulposus (NP) is of critical importance for treating intervertebral disc degeneration (IDD). Here, we aimed to elucidate the detailed molecular mechanism of NP ossification and IDD using s...

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Bibliographic Details
Main Authors: Song Guo, Meijun Yan, Xinhua Li, Shuya Zhang, Zhong Liu, Kewei Li, Pengcheng Liu, Yanbin Liu, Guixin Sun, Qiang Fu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
single-cell RNA-seq analysis
IDD
nucleus pulposus
ossification
TNF-α
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1224627/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1224627/full

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