Segregation of a latent high adiposity phenotype in families with a history of type 2 diabetes mellitus implicates rare obesity-susceptibility genetic variants with large effects in diabetes-related obesity.

Segregation of a latent high adiposity phenotype in families with a history of type 2 diabetes mellitus implicates rare obesity-susceptibility genetic variants with large effects in diabetes-related obesity.

BACKGROUND: We recently reported significantly greater weight gain in non-diabetic healthy subjects with a 1(st) degree family history (FH+) of type 2 diabetes mellitus (T2DM) than in a matched control group without such history (FH-) during voluntary overfeeding, implying co-inheritance of suscepti...

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Bibliographic Details
Main Authors: Arthur B Jenkins, Marijka Batterham, Dorit Samocha-Bonet, Katherine Tonks, Jerry R Greenfield, Lesley V Campbell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3737254?pdf=render

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http://europepmc.org/articles/PMC3737254?pdf=render

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