Using the mouse to model human disease: increasing validity and reproducibility

Experiments that use the mouse as a model for disease have recently come under scrutiny because of the repeated failure of data, particularly derived from preclinical studies, to be replicated or translated to humans. The usefulness of mouse models has been questioned because of irreproducibility an...

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Bibliographic Details
Main Authors: Monica J. Justice, Paraminder Dhillon
Format: Article
Language:English
Published: The Company of Biologists 2016-02-01
Series:Disease Models & Mechanisms
Online Access:http://dmm.biologists.org/content/9/2/101