Upregulation of TLR4/MyD88 pathway in alcohol-induced Wernicke’s encephalopathy: Findings in preclinical models and in a postmortem human case

Upregulation of TLR4/MyD88 pathway in alcohol-induced Wernicke’s encephalopathy: Findings in preclinical models and in a postmortem human case

Wernicke’s encephalopathy (WE) is a neurologic disease caused by vitamin B1 or thiamine deficiency (TD), being the alcohol use disorder its main risk factor. WE patients present limiting motor, cognitive, and emotional alterations related to a selective cerebral vulnerability. Neuroinflammation has...

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Bibliographic Details
Main Authors: Marta Moya, Berta Escudero, Elena Gómez-Blázquez, Ana Belen Rebolledo-Poves, Meritxell López-Gallardo, Carmen Guerrero, Eva M. Marco, Laura Orio
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
Wernicke–Korsakoff syndrome
neuroinflammation
frontal cortex
cerebellum
thiamine deficiency
alcohol use disorder (AUD)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.866574/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.866574/full

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