Statistical methods and graphical displays of quality of life with survival outcomes in oncology clinical trials for supporting the estimand framework

Statistical methods and graphical displays of quality of life with survival outcomes in oncology clinical trials for supporting the estimand framework

Abstract Background Although there are discussions regarding standards of the analysis of patient-reported outcomes and quality of life (QOL) in oncology clinical trials, that of QOL with death events is not within their scope. For example, ignoring death can lead to bias in the QOL analysis for pat...

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Bibliographic Details
Main Authors: Kentaro Sakamaki, Takuya Kawahara
Format: Article
Language:English
Published: BMC 2022-10-01
Series:BMC Medical Research Methodology
Subjects:
Quality of life
Truncation by death
Estimand framework
Graphical displays
Prioritized composite outcome
Semi-competing risk analysis
Online Access:https://doi.org/10.1186/s12874-022-01735-1

Internet

https://doi.org/10.1186/s12874-022-01735-1

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