2-octynoic acid inhibits hepatitis C virus infection through activation of AMP-activated protein kinase.

2-octynoic acid inhibits hepatitis C virus infection through activation of AMP-activated protein kinase.

Many chronic hepatitis C virus (HCV)-infected patients with current therapy do not clear the virus. It is necessary to find novel treatments. The effect of 2-octynoic acid (2-OA) on HCV infection in human hepatocytes was examined. The mechanism of 2-OA antiviral activity was explored. Our data showe...

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Bibliographic Details
Main Authors: Darong Yang, Binbin Xue, Xiaohong Wang, Xiaoyan Yu, Nianli Liu, Yimin Gao, Chen Liu, Haizhen Zhu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3669134?pdf=render

Internet

http://europepmc.org/articles/PMC3669134?pdf=render

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