Fibroblast growth factors preserve blood–brain barrier integrity through RhoA inhibition after intracerebral hemorrhage in mice

Fibroblast growth factors preserve blood–brain barrier integrity through RhoA inhibition after intracerebral hemorrhage in mice

Fibroblast growth factors (FGFs) maintain and promote vascular integrity; however whether FGFs protect the blood–brain barrier (BBB) after intracerebral hemorrhage (ICH) remains unexplored. In this present study, we hypothesized that exogenous FGF administration attenuates brain injury after ICH, sp...

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Bibliographic Details
Main Authors: Bin Huang, Paul R. Krafft, Qingyi Ma, William B. Rolland, Basak Caner, Tim Lekic, Anatol Manaenko, Mai Le, Jiping Tang, John H. Zhang
Format: Article
Language:English
Published: Elsevier 2012-04-01
Series:Neurobiology of Disease
Subjects:
Fibroblast growth factor
Thrombin
Rac1
RhoA
Intracerebral hemorrhage
Brain injury
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611200023X

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http://www.sciencedirect.com/science/article/pii/S096999611200023X

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