A systematic survey of randomised trials that stopped early for reasons of futility
Abstract Background Randomised trial protocols may incorporate interim analyses, with the potential to stop the study for futility if early data show insufficient promise of a treatment benefit. Previously, we have shown that this approach will theoretically lead to mis-estimation of the treatment e...
| Principais autores: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
BMC
2020-01-01
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| coleção: | BMC Medical Research Methodology |
| Assuntos: | |
| Acesso em linha: | https://doi.org/10.1186/s12874-020-0899-1 |