A tumor suppressor role for EZH2 in diffuse midline glioma pathogenesis

A tumor suppressor role for EZH2 in diffuse midline glioma pathogenesis

Abstract Pediatric high-grade gliomas, specifically diffuse midline gliomas, account for only 20% of clinical cases but are 100% fatal. A majority of the DMG cases are characterized by the signature K27M mutation in histone H3. The H3K27M mutation opposes the function of enhancer of zeste homolog 2...

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Bibliographic Details
Main Authors: Swati Dhar, Samantha Gadd, Priyam Patel, Jake Vaynshteyn, G. Praveen Raju, Rintaro Hashizume, Daniel J. Brat, Oren J. Becher
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Acta Neuropathologica Communications
Subjects:
Ezh2 loss-of-function
Ezh2 gain-of-function
Diffuse midline gliomas (DMGs)
Tumor suppressor
Interferon gamma
Oxidative phosphorylation
Online Access:https://doi.org/10.1186/s40478-022-01336-5

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https://doi.org/10.1186/s40478-022-01336-5

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