A tumor suppressor role for EZH2 in diffuse midline glioma pathogenesis

A tumor suppressor role for EZH2 in diffuse midline glioma pathogenesis

Abstract Pediatric high-grade gliomas, specifically diffuse midline gliomas, account for only 20% of clinical cases but are 100% fatal. A majority of the DMG cases are characterized by the signature K27M mutation in histone H3. The H3K27M mutation opposes the function of enhancer of zeste homolog 2...

Full description

Bibliographic Details
Main Authors: Swati Dhar, Samantha Gadd, Priyam Patel, Jake Vaynshteyn, G. Praveen Raju, Rintaro Hashizume, Daniel J. Brat, Oren J. Becher
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Acta Neuropathologica Communications
Subjects:
Ezh2 loss-of-function
Ezh2 gain-of-function
Diffuse midline gliomas (DMGs)
Tumor suppressor
Interferon gamma
Oxidative phosphorylation
Online Access:https://doi.org/10.1186/s40478-022-01336-5

Similar Items

Similar Items