Curcumin Analogue L48H37 Suppresses Human Osteosarcoma U2OS and MG-63 Cells’ Migration and Invasion in Culture by Inhibition of uPA via the JAK/STAT Signaling Pathway

Curcumin Analogue L48H37 Suppresses Human Osteosarcoma U2OS and MG-63 Cells’ Migration and Invasion in Culture by Inhibition of uPA via the JAK/STAT Signaling Pathway

Osteosarcoma, the most prevalent malignant bone tumor in the pediatric age group, is responsible for the great majority of cancer-associated deaths owing to its highly metastatic potential. The anti-metastatic effects of the new curcumin analogue L48H37 in human osteosarcoma are still unknown; hence...

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Bibliographic Details
Main Authors: Ko-Hsiu Lu, Heng-Hsiung Wu, Renn-Chia Lin, Ya-Chiu Lin, Peace Wun-Ang Lu, Shun-Fa Yang, Jia-Sin Yang
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Molecules
Subjects:
L48H37
migration
osteosarcoma
JAK/STAT
uPA
Online Access:https://www.mdpi.com/1420-3049/26/1/30

Internet

https://www.mdpi.com/1420-3049/26/1/30

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