Transgenic disruption of endogenous glucocorticoid signaling in osteoblasts does not alter long-term K/BxN serum transfer-induced arthritis

Transgenic disruption of endogenous glucocorticoid signaling in osteoblasts does not alter long-term K/BxN serum transfer-induced arthritis

Abstract Background Disruption of glucocorticoid (GC) signaling in osteoblasts results in a marked attenuation of acute antibody-induced arthritis. The role of endogenous GCs in chronic inflammatory arthritis is however not fully understood. Here, we investigated the impact of endogenous GC signalin...

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Bibliographic Details
Main Authors: Tazio Maleitzke, Edgar Wiebe, Dörte Huscher, Cornelia M. Spies, Jinwen Tu, Timo Gaber, Yu Zheng, Frank Buttgereit, Markus J. Seibel, Hong Zhou
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Arthritis Research & Therapy
Subjects:
11ß-HSD2
Cortisol
Cortisone
Rheumatoid arthritis
Antibody
Joint inflammation
Online Access:https://doi.org/10.1186/s13075-023-03112-9

Internet

https://doi.org/10.1186/s13075-023-03112-9

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