Transgenic disruption of endogenous glucocorticoid signaling in osteoblasts does not alter long-term K/BxN serum transfer-induced arthritis

Transgenic disruption of endogenous glucocorticoid signaling in osteoblasts does not alter long-term K/BxN serum transfer-induced arthritis

Abstract Background Disruption of glucocorticoid (GC) signaling in osteoblasts results in a marked attenuation of acute antibody-induced arthritis. The role of endogenous GCs in chronic inflammatory arthritis is however not fully understood. Here, we investigated the impact of endogenous GC signalin...

Celý popis

Podrobná bibliografie
Hlavní autoři: Tazio Maleitzke, Edgar Wiebe, Dörte Huscher, Cornelia M. Spies, Jinwen Tu, Timo Gaber, Yu Zheng, Frank Buttgereit, Markus J. Seibel, Hong Zhou
Médium: Článek
Jazyk:English
Vydáno: BMC 2023-08-01
Edice:Arthritis Research & Therapy
Témata:
11ß-HSD2
Cortisol
Cortisone
Rheumatoid arthritis
Antibody
Joint inflammation
On-line přístup:https://doi.org/10.1186/s13075-023-03112-9

Internet

https://doi.org/10.1186/s13075-023-03112-9

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