Sertoli Cell-Specific Activation of Transforming Growth Factor Beta Receptor 1 Leads to Testicular Granulosa Cell Tumor Formation

The transforming growth factor β (TGFβ) superfamily, consisting of protein ligands, receptors, and intracellular SMAD transducers, regulates fundamental biological processes and cancer development. Our previous study has shown that sustained activation of TGFβ receptor 1 (TGFBR1) driven by anti-Mull...

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Bibliographic Details
Main Authors: Xin Fang, Linfeng Nie, Satwikreddy Putluri, Nan Ni, Laurent Bartholin, Qinglei Li
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/12/23/2717