<i>Orientia tsutsugamushi</i> Infection Stimulates Syk-Dependent Responses and Innate Cytosolic Defenses in Macrophages

<i>Orientia tsutsugamushi</i> Infection Stimulates Syk-Dependent Responses and Innate Cytosolic Defenses in Macrophages

<i>Orientia tsutsugamushi</i> is an obligately intracellular bacterium and an etiological agent of scrub typhus. Human studies and animal models of scrub typhus have shown robust type 1-skewed proinflammatory responses during severe infection. Macrophages (MΦ) play a critical role in ini...

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Bibliographic Details
Main Authors: James Fisher, Casey Gonzales, Zachary Chroust, Yuejin Liang, Lynn Soong
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pathogens
Subjects:
<i>Orientia</i>
obligate intracellular bacteria
innate immunity
pattern recognition receptor
Syk
C-type lectin
Online Access:https://www.mdpi.com/2076-0817/12/1/53

Internet

https://www.mdpi.com/2076-0817/12/1/53

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