Influence of T Cell-Mediated Immune Surveillance on Somatic Mutation Occurrences in Melanoma

Influence of T Cell-Mediated Immune Surveillance on Somatic Mutation Occurrences in Melanoma

BackgroundNeoantigens are presented on the cancer cell surface by peptide-restricted human leukocyte antigen (HLA) proteins and can subsequently activate cognate T cells. It has been hypothesized that the observed somatic mutations in tumors are shaped by immunosurveillance.MethodsWe investigated al...

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Bibliographic Details
Main Authors: Chongming Jiang, Evelien Schaafsma, Wei Hong, Yanding Zhao, Ken Zhu, Cheng-Chi Chao, Chao Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
Melanoma
recurrent mutation
immunosurveillance
neoantigen
antigen presentation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.703821/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.703821/full

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