Circular RNA circBNC2 inhibits epithelial cell G2-M arrest to prevent fibrotic maladaptive repair

G2/M arrest of epithelial cells leads to fibrosis with unclear mechanisms. This study identifies a protein-encoding circRNA, circBNC2, which inhibits epithelial cells G2/M arrest to prevent fibrotic maladaptive repair in damaged kidney and liver, revealing a potential intervention target for fibrosi...

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Bibliographic Details
Main Authors: Peng Wang, Zhitao Huang, Yili Peng, Hongwei Li, Tong Lin, Yingyu Zhao, Zheng Hu, Zhanmei Zhou, Weijie Zhou, Youhua Liu, Fan Fan Hou
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34287-5