The PTPIP51 coiled-coil domain is important in VAPB binding, formation of ER-mitochondria contacts and IP3 receptor delivery of Ca2+ to mitochondria

The PTPIP51 coiled-coil domain is important in VAPB binding, formation of ER-mitochondria contacts and IP3 receptor delivery of Ca2+ to mitochondria

Signaling between the endoplasmic reticulum (ER) and mitochondria regulates a number of fundamental physiological processes. This signaling involves close physical contacts between the two organelles that are mediated by the VAPB-PTPIP51 ″tethering” proteins. The VAPB-PTPIP51 tethers facilitate inos...

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Bibliographic Details
Main Authors: Gábor M. Mórotz, Sandra M. Martín-Guerrero, Andrea Markovinovic, Sebastien Paillusson, Matthew R. G. Russell, Pedro M. Pereira Machado, Roland A. Fleck, Wendy Noble, Christopher C.J. Miller
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Alzheimer’s disease
Parkinson’s disease
amyotrofic lateral sclerosis
dementia
endoplasmic reticulum
mitochondria
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.920947/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.920947/full

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