The promiscuous development of an unconventional Qa1b-restricted T cell population

The promiscuous development of an unconventional Qa1b-restricted T cell population

MHC-E restricted CD8 T cells show promise in vaccine settings, but their development and specificity remain poorly understood. Here we focus on a CD8 T cell population reactive to a self-peptide (FL9) bound to mouse MHC-E (Qa-1b) that is presented in response to loss of the MHC I processing enzyme E...

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Bibliographic Details
Main Authors: Michael Manoharan Valerio, Kathya Arana, Jian Guan, Shiao Wei Chan, Xiaokun Yang, Nadia Kurd, Angus Lee, Nilabh Shastri, Laurent Coscoy, Ellen A. Robey
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
MHC-E
T cell development
unconventional T cells
non-classical MHC-1
IEL
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1250316/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1250316/full

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