Efficient secretory production of proline/alanine/serine (PAS) biopolymers in Corynebacterium glutamicum yielding a monodisperse biological alternative to polyethylene glycol (PEG)

Efficient secretory production of proline/alanine/serine (PAS) biopolymers in Corynebacterium glutamicum yielding a monodisperse biological alternative to polyethylene glycol (PEG)

Abstract Background PAS biopolymers are recombinant polypeptides comprising the small uncharged l-amino acids Pro, Ala and/or Ser which resemble the widely used poly-ethylene glycol (PEG) in terms of pronounced hydrophilicity. Likewise, their random chain behaviour in physiological solution results...

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Bibliographic Details
Main Authors: L. Friedrich, Y. Kikuchi, Y. Matsuda, U. Binder, A. Skerra
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Microbial Cell Factories
Subjects:
Disordered polypeptide
Hydrophilic polymer
PASylation
PEG
Pro/Ala/Ser
Online Access:https://doi.org/10.1186/s12934-022-01948-5

Internet

https://doi.org/10.1186/s12934-022-01948-5

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