Structurally-discovered KLF4 variants accelerate and stabilize reprogramming to pluripotency

Structurally-discovered KLF4 variants accelerate and stabilize reprogramming to pluripotency

Summary: Non-genetically modified somatic cells can only be inefficiently and stochastically reprogrammed to pluripotency by exogenous expression of reprogramming factors. Low competence of natural reprogramming factors may prevent the majority of cells to successfully and synchronously reprogram. H...

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Bibliographic Details
Main Authors: Evgeniia Borisova, Ken Nishimura, Yuri An, Miho Takami, Jingyue Li, Dan Song, Mami Matsuo-Takasaki, Dorian Luijkx, Shiho Aizawa, Akihiro Kuno, Eiji Sugihara, Taka-aki Sato, Fumiaki Yumoto, Tohru Terada, Koji Hisatake, Yohei Hayashi
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:iScience
Subjects:
Stem cell plasticity
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221014966

Internet

http://www.sciencedirect.com/science/article/pii/S2589004221014966

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