Effect of Subthalamic Stimulation and Electrode Implantation in the Striatal Microenvironment in a Parkinson’s Disease Rat Model

Effect of Subthalamic Stimulation and Electrode Implantation in the Striatal Microenvironment in a Parkinson’s Disease Rat Model

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is considered the gold-standard treatment for PD; however, underlying therapeutic mechanisms need to be comprehensively elucidated, especially in relation to glial cells. We aimed to understand the effects of STN-microlesions and STN-DBS...

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Bibliographic Details
Main Authors: Ana Carolina Pinheiro Campos, Raquel Chacon Ruiz Martinez, Aline Vivian Vatti Auada, Ivo Lebrun, Erich Talamoni Fonoff, Clement Hamani, Rosana Lima Pagano
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
Parkinson’s disease
deep brain stimulation
subthalamic stimulation
neuroinflammation
astrocytes
glutamate excitotoxicity
Online Access:https://www.mdpi.com/1422-0067/23/20/12116

Internet

https://www.mdpi.com/1422-0067/23/20/12116

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