Rapid and efficient conversion of integration-free human induced pluripotent stem cells to GMP-grade culture conditions.

Rapid and efficient conversion of integration-free human induced pluripotent stem cells to GMP-grade culture conditions.

Data suggest that clinical applications of human induced pluripotent stem cells (hiPSCs) will be realized. Nonetheless, clinical applications will require hiPSCs that are free of exogenous DNA and that can be manufactured through Good Manufacturing Practice (GMP). Optimally, derivation of hiPSCs sho...

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Bibliographic Details
Main Authors: Jens Durruthy-Durruthy, Sharon F Briggs, Jason Awe, Cyril Y Ramathal, Saravanan Karumbayaram, Patrick C Lee, Julia D Heidmann, Amander Clark, Ioannis Karakikes, Kyle M Loh, Joseph C Wu, Andrew R Hoffman, James Byrne, Renee A Reijo Pera, Vittorio Sebastiano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3981795?pdf=render

Internet

http://europepmc.org/articles/PMC3981795?pdf=render

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