High-level production of γ-aminobutyric acid via efficient co-expression of the key genes of glutamate decarboxylase system in Escherichia coli

High-level production of γ-aminobutyric acid via efficient co-expression of the key genes of glutamate decarboxylase system in Escherichia coli

Biosynthesis of the functional factor γ-aminobutyric acid (GABA) in bacteria involves two key proteins an intracellular glutamate decarboxylase (GadB) and a membrane-bound antiporter (GadC). Efficient co-expression of suitable GadB and GadC candidates is crucial for improving GABA productivity. In t...

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Bibliographic Details
Main Authors: Lili Yao, Changjiang Lyu, Yuting Wang, Sheng Hu, Weirui Zhao, Hongwei Cao, Jun Huang, Lehe Mei
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Engineering Microbiology
Subjects:
Glutamate decarboxylase
Antiporter
γ-Aminobutyric acid
E. coli
Whole-cell biocatalysts
Online Access:http://www.sciencedirect.com/science/article/pii/S2667370323000097

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http://www.sciencedirect.com/science/article/pii/S2667370323000097

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