Deep blue autofluorescence reflects the oxidation state of human transthyretin

Human transthyretin (TTR) is a tetrameric protein transporting thyroid hormones and retinol. TTR is a neuroprotective factor and sensor of oxidative stress which stability is diminished due to mutations and aging, leading to amyloid deposition. Adverse environmental conditions, such as redox and met...

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Bibliographic Details
Main Authors: Elżbieta Wieczorek, Zofia Wygralak, Sylwia Kędracka-Krok, Patrycja Bezara, Dominika Bystranowska, Piotr Dobryszycki, Andrzej Ożyhar
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Redox Biology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722002063