Increased O-GlcNAcylation of Endothelial Nitric Oxide Synthase Compromises the Anti-contractile Properties of Perivascular Adipose Tissue in Metabolic Syndrome

Increased O-GlcNAcylation of Endothelial Nitric Oxide Synthase Compromises the Anti-contractile Properties of Perivascular Adipose Tissue in Metabolic Syndrome

Under physiological conditions, the perivascular adipose tissue (PVAT) negatively modulates vascular contractility. This property is lost in experimental and human obesity and in the metabolic syndrome, indicating that changes in PVAT function may contribute to vascular dysfunction associated with i...

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Bibliographic Details
Main Authors: Rafael M. da Costa, Josiane F. da Silva, Juliano V. Alves, Thiago B. Dias, Diane M. Rassi, Luis V. Garcia, Núbia de Souza Lobato, Rita C. Tostes
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Physiology
Subjects:
PVAT
O-GlcNAc
high-sugar diet
eNOS
vascular function
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00341/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2018.00341/full

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