Design, synthesis and biological evaluation of 2-((4-sulfamoylphenyl)amino)-pyrrolo[2,3-d]pyrimidine derivatives as CDK inhibitors

Design, synthesis and biological evaluation of 2-((4-sulfamoylphenyl)amino)-pyrrolo[2,3-d]pyrimidine derivatives as CDK inhibitors

To explore the potential use of CDK inhibitors in pancreatic ductal adenocarcinoma (PDAC) therapy, a series of novel 2-((4-sulfamoylphenyl)amino)-pyrrolo[2,3-d]pyrimidine derivatives was designed, synthesised, and investigated for inhibition on both CDK kinase activity and cellular proliferation of...

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Bibliographic Details
Main Authors: Bo Yang, Yanni Quan, Wuli Zhao, Yingjie Ji, Xiaotang Yang, Jianrui Li, Yi Li, Xiujun Liu, Ying Wang, Yanping Li
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Cell cycle-dependent kinase inhibitor
2-((4-sulfamoylphenyl)amino)-pyrrolo[23-d]pyrimidine derivatives
pancreatic ductal adenocarcinoma
anti-proliferative activity
oral pharmacokinetics
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2023.2169282

Internet

https://www.tandfonline.com/doi/10.1080/14756366.2023.2169282

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