Clinical Considerations for a Family with Dilated Cardiomyopathy, Sudden Cardiac Death, and a Novel <i>TTN</i> Frameshift Mutation

Clinical Considerations for a Family with Dilated Cardiomyopathy, Sudden Cardiac Death, and a Novel <i>TTN</i> Frameshift Mutation

Dilated cardiomyopathy (DCM) is the leading indication for heart transplantation. <i>TTN</i> gene truncating mutations account for about 25% of familial DCM cases and for 18% of sporadic DCM cases. The clinical relevance of specific variants in <i>TTN</i> has been difficult t...

Full description

Bibliographic Details
Main Authors: Emanuele Micaglio, Michelle M. Monasky, Andrea Bernardini, Valerio Mecarocci, Valeria Borrelli, Giuseppe Ciconte, Emanuela T. Locati, Marco Piccoli, Andrea Ghiroldi, Luigi Anastasia, Carlo Pappone
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
dilated cardiomyopathy
<i>TTN</i>
titin
sudden cardiac death
genetic testing
mutation
Online Access:https://www.mdpi.com/1422-0067/22/2/670

Internet

https://www.mdpi.com/1422-0067/22/2/670

Similar Items