Distinct mechanisms regulate Lck spatial organization in activated T cells

Distinct mechanisms regulate Lck spatial organization in activated T cells

Phosphorylation of the T cell receptor (TCR) by the kinase Lck is the first detectable signaling event upon antigen engagement. The distribution of Lck within the plasma membrane, its conformational state, kinase activity and protein interactions all contribute to determine how efficiently Lck phosp...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Natasha eKapoor-Kaushik, Elizabeth eHinde, Ewoud Bernardus Compeer, Yui eYamamoto, Felix eKraus, Zhengmin eYang, Jieqiong eLou, Thibault eTabarin, Sophie Victoria Pageon, Katharina eGaus, Jeremie eRossy
Format: Artikel
Sprache:English
Veröffentlicht: Frontiers Media S.A. 2016-03-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
Lck
T cell signaling
Membrane organization
image correlation spectroscopy
Super-resolution fluorescence microscopy
assembly of signaling complexes
Online Zugang:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00083/full

Online

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00083/full

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