Distinct mechanisms regulate Lck spatial organization in activated T cells

Distinct mechanisms regulate Lck spatial organization in activated T cells

Phosphorylation of the T cell receptor (TCR) by the kinase Lck is the first detectable signaling event upon antigen engagement. The distribution of Lck within the plasma membrane, its conformational state, kinase activity and protein interactions all contribute to determine how efficiently Lck phosp...

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Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Natasha eKapoor-Kaushik, Elizabeth eHinde, Ewoud Bernardus Compeer, Yui eYamamoto, Felix eKraus, Zhengmin eYang, Jieqiong eLou, Thibault eTabarin, Sophie Victoria Pageon, Katharina eGaus, Jeremie eRossy
Formáid: Alt
Teanga:English
Foilsithe / Cruthaithe: Frontiers Media S.A. 2016-03-01
Sraith:Frontiers in Immunology
Ábhair:
Lck
T cell signaling
Membrane organization
image correlation spectroscopy
Super-resolution fluorescence microscopy
assembly of signaling complexes
Rochtain ar líne:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00083/full

Ar líne

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00083/full

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