The solution surface of the Li-Stephens haplotype copying model

Abstract The Li-Stephens (LS) haplotype copying model forms the basis of a number of important statistical inference procedures in genetics. LS is a probabilistic generative model which supposes that a sampled chromosome is an imperfect mosaic of other chromosomes found in a population. In the frequ...

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Bibliographic Details
Main Authors: Yifan Jin, Jonathan Terhorst
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Algorithms for Molecular Biology
Subjects:
Online Access:https://doi.org/10.1186/s13015-023-00237-z