Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes

Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes

Summary: The therapeutic mechanism of metformin action remains incompletely understood. Whether metformin inhibits glucagon-stimulated endogenous glucose production (EGP), as in preclinical studies, is unclear in humans. To test this hypothesis, we studied nine prediabetic individuals using a random...

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Bibliographic Details
Main Authors: Adam R. Konopka, Raul Ruiz Esponda, Matthew M. Robinson, Matthew L. Johnson, Rickey E. Carter, Michele Schiavon, Claudio Cobelli, Fredric E. Wondisford, Ian R. Lanza, K. Sreekumaran Nair
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716304375

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http://www.sciencedirect.com/science/article/pii/S2211124716304375

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