Estimation of an Appropriate Dose of Trazodone for Pediatric Insomnia and the Potential for a Trazodone–Atomoxetine Interaction

There is a paucity of clinical trials for the treatment of pediatric insomnia. This study was designed to predict the doses of trazodone to guide dosing in a clinical trial for pediatric insomnia using physiologically‐based pharmacokinetic (PBPK) modeling. Data on the pharmacokinetics of trazodone i...

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Bibliographic Details
Main Authors: Laura Oggianu, Alice B. Ke, Manoranjenni Chetty, Rossella Picollo, Vanessa Petrucci, Fabrizio Calisti, Fabio Garofolo, Serena Tongiani
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Online Access:https://doi.org/10.1002/psp4.12480