Characterization of diseased primary human hepatocytes in an all-human cell-based triculture system

Abstract Liver diseases, including NAFLD, are a growing worldwide health concern. Currently, there is a lack of suitable in vitro models that sustain basic primary human hepatocyte (PHH) morphology and functionality while supporting presentation of disease-associated phenotypic characteristics such...

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Bibliographic Details
Main Authors: Justin J. Odanga, Sharon M. Anderson, Erick K. Breathwaite, Sharon C. Presnell, Edward L. LeCluyse, Jingsong Chen, Jessica R. Weaver
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-024-57463-7