Biophysical and Biochemical Characterization of TP0037, a <sc>d</sc>-Lactate Dehydrogenase, Supports an Acetogenic Energy Conservation Pathway in <named-content content-type="genus-species">Treponema pallidum</named-content>

Biophysical and Biochemical Characterization of TP0037, a <sc>d</sc>-Lactate Dehydrogenase, Supports an Acetogenic Energy Conservation Pathway in <named-content content-type="genus-species">Treponema pallidum</named-content>

ABSTRACT A longstanding conundrum in Treponema pallidum biology concerns how the spirochete generates sufficient energy to fulfill its complex pathogenesis processes during human syphilitic infection. For decades, it has been assumed that the bacterium relies solely on glucose catabolism (via glycol...

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Bibliographic Details
Main Authors: Ranjit K. Deka, Wei Z. Liu, Michael V. Norgard, Chad A. Brautigam
Format: Article
Language:English
Published: American Society for Microbiology 2020-10-01
Series:mBio
Subjects:
d-lactate dehydrogenase
Treponema pallidum
X-ray crystallography
acetogenesis
spirochetes
Online Access:https://journals.asm.org/doi/10.1128/mBio.02249-20

Internet

https://journals.asm.org/doi/10.1128/mBio.02249-20

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