LINC00963-FOSB-mediated transcription activation of UBE3C enhances radioresistance of breast cancer cells by inducing ubiquitination-dependent protein degradation of TP73

LINC00963-FOSB-mediated transcription activation of UBE3C enhances radioresistance of breast cancer cells by inducing ubiquitination-dependent protein degradation of TP73

Abstract Background The ubiquitin protein ligase E3C (UBE3C) has been reported to play an oncogenic role in breast cancer (BRCA). This work further investigates the effect of UBE3C on the radioresistance of BRCA cells. Methods Molecules linking to radioresistance in BRCA were identified by analyzing...

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Bibliographic Details
Main Authors: Yansu Wang, Ming Liu, Xiaoqian Liu, Xianling Guo
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Journal of Translational Medicine
Subjects:
Breast cancer
Radioresistance
FOSB
UBE3C
TP73
Ubiquitination
Online Access:https://doi.org/10.1186/s12967-023-04153-z

Internet

https://doi.org/10.1186/s12967-023-04153-z

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