HexA-Enzyme Coated Polymer Nanoparticles for the Development of a Drug-Delivery System in the Treatment of Sandhoff Lysosomal Storage Disease

HexA-Enzyme Coated Polymer Nanoparticles for the Development of a Drug-Delivery System in the Treatment of Sandhoff Lysosomal Storage Disease

Lysosomal storage disorders (LSDs) are a set of metabolic diseases caused by mutations in genes that are in charge of the production of lysosomal enzymes, resulting in the buildup of non-degraded substrates and the consequent systemic damage that mainly involves the Central Nervous System (CNS). One...

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Bibliographic Details
Main Authors: Eleonora Calzoni, Alessio Cesaretti, Nicolò Montegiove, Alessandro Di Michele, Roberto Maria Pellegrino, Carla Emiliani
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Journal of Functional Biomaterials
Subjects:
lysosomal storage disorders
covalent immobilization
biopolymer nanoparticles
enzyme replacement therapy
restored activity
ganglioside degradation
Online Access:https://www.mdpi.com/2079-4983/13/2/37

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https://www.mdpi.com/2079-4983/13/2/37

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